Elk1

Elk1 (also known as p62 ternary complex factor, TCF) is an Ets-related transcription factor that mediates growth factor stimulation of the c-fos promoter. Elk1 binds to DNA in part via interaction with Serum Response Factor. While Elk1 is a bona fide Erk substrate, it remains unclear whether Elk1 is regulated by the SAPK pathway since certain residues important for transcriptional activation are poorly phosphorylated by SAPKs compared with Erk2. However, SAPK phosphorylation of Elk1 may mediate transcriptional activation of the fos promoter in response to a variety of stresses.

References

Gille, H., Strahl, T. and Shaw, P.E. (1995). Activation of Ternary Complex Factor Elk-1 by Stress-Activated Protein Kinases. Current Biology (in press)

Marais, R., Wynne, J. and Treisman, R. (1993) The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73, 383-393

Price, M.A., Rogers A.E. and Treisman, R. (1995) Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET) EMBO J 14, 2589-2601

Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269, 403-407

Price, M.A., Cruzalegui, F.H. and Treisman, R. (1996) The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. EMBO J. 15, 6552-6563.


We're not working on Elk1 and so rely on published data from others for this page. If you do work on Elk1 and would like to contribute information to this map, let me know and I'll show you how. You'll be cyberspaced in no time!


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